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Coronavirus (COVID-19) Update
At Exelixis, we remain committed to serving the needs of people who take CABOMETYX. We do not anticipate any impact to the availability of the medicine. All our financial and patient support services also remain fully operational. We are monitoring the situation so that we can continue to make the best decisions for the safety, health, and well-being of you as well as our employees.

You can get more information on our corporate website here.

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Tips for Caregivers

You are an essential part of your loved one’s treatment circle. There are many things you can do to help.

Caregiver Tip; Know what to expect
Know what to expect
  • Find out as much as you can about your loved one’s diagnosis and treatment
    • You’ll have a better idea of what to expect during your loved one’s journey
  • Understand the dosing schedule and potential side effects of CABOMETYX
    • You can help your loved one keep an eye on both—especially side effects, since some can be managed
Caregiver Tip; Go to doctors appointments
Go along to doctor’s appointments
  • Go to checkups with your loved one
    • He or she will have a second pair of ears listening to the oncology doctor or nurse
  • Come prepared with questions to ask the oncology doctor or nurse
    • Make sure you get all the answers you’re looking for
  • Take notes and speak up!
    • Don’t be afraid to ask questions if you don’t understand something
Caregiver Tip; Get organized
Get organized
  • Try to be as organized as possible
    • There’s a lot of paperwork in healthcare to keep track of
    • Make sure you have a place to store important documents so you can find them easily
Caregiver Tip; Take care of yourself
Take care of yourself
  • Join a support group
    • This way you can spend time with people who also have a loved one living with cancer
  • Set aside time to do something you enjoy like taking a walk, reading a book, or watching your favorite show
  • Stay healthy!
    • Go to the doctor for checkups, stay active, and eat healthy foods like fruits, vegetables, and protein-filled nuts and yogurt
  • Don’t be too hard on yourself
    • You are learning to be a caregiver every day, and with learning there may come times when you feel you should have done something differently. Don’t focus on that. Instead focus on the positive things you’re doing for your loved one

Download a PDF of Tips for Caregivers

Caring for someone starting CABOMETYX?
Learn more about the $0 Co-Pay Card*
*Eligibility rules apply

Additional ways to get support

Organizations designed to support you and your loved one

Here are some support organizations you may want to read about or get in touch with.

Cancer organizations

American Cancer Society®

CancerCare®

The National Cancer Institute: Comprehensive Cancer Information

NCCN®*

Kidney Cancer Organizations

KCCure

Kidney Cancer Association

National Kidney Foundation®

Liver Cancer Organizations

American Liver Foundation

Blue Faery: The Adrienne Wilson Liver Cancer Association

*Linked with permission from the National Comprehensive Cancer Network, Inc. All rights reserved. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.

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INDICATIONS AND IMPORTANT SAFETY INFORMATION


What is CABOMETYX?

CABOMETYX is a prescription medicine used to treat people with:

It is not known if CABOMETYX is safe and effective in children.

 

INDICATIONS AND IMPORTANT SAFETY INFORMATION


What is CABOMETYX?

CABOMETYX is a prescription medicine used to treat people with:

  • Advanced kidney cancer (renal cell carcinoma)
  • Liver cancer (hepatocellular carcinoma) who have been previously treated with the medicine sorafenib.

It is not known if CABOMETYX is safe and effective in children.

What are the possible side effects of CABOMETYX?


CABOMETYX may cause serious side effects, including:

Bleeding (hemorrhage). CABOMETYX can cause severe bleeding that may lead to death. Tell your healthcare provider right away if you get any signs of bleeding during treatment with CABOMETYX, including:

  • Coughing up blood or blood clots
  • Vomiting blood or if your vomit looks like coffee grounds
  • Red or black (looks like tar) stools
  • Menstrual bleeding that is heavier than normal
  • Any unusual or heavy bleeding

A tear in your stomach or intestinal wall (perforation) or an abnormal connection between 2 parts of your body (fistula). Tell your healthcare provider right away if you get tenderness or pain in your stomach area (abdomen).

Blood clots, stroke, heart attack, and chest pain. Get emergency help right away if you get:

  • Swelling or pain in your arms or legs
  • Shortness of breath
  • Feel lightheaded or faint
  • Sweating more than usual
  • Numbness or weakness of your face, arm or leg, especially on one side of your body
  • Sudden confusion, trouble speaking or understanding
  • Sudden trouble seeing in one or both eyes
  • Sudden trouble walking
  • Dizziness, loss of balance or coordination
  • A sudden severe headache

High blood pressure (hypertension). Hypertension is common with CABOMETYX and sometimes can be severe. Your healthcare provider will check your blood pressure before starting CABOMETYX and during treatment with CABOMETYX. If needed, your healthcare provider may prescribe medicine to treat your high blood pressure.

Diarrhea. Diarrhea is common with CABOMETYX and can be severe. If needed, your healthcare provider may prescribe medicine to treat your diarrhea. Tell your healthcare provider right away if you have frequent loose, watery bowel movements.

A skin problem called hand-foot skin reaction. Hand-foot skin reactions are common and can be severe. Tell your healthcare provider right away if you have rashes, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet.

Protein in your urine and possible kidney problems. Symptoms may include swelling in your hands, arms, legs, or feet.

Severe jaw bone problems (osteonecrosis). Symptoms may include jaw pain, toothache, or sores on your gums. Your healthcare provider should examine your mouth before you start and during treatment with CABOMETYX. Tell your dentist that you are taking CABOMETYX. It is important for you to practice good mouth care during treatment with CABOMETYX.

Wound healing problems. Wound healing problems have happened in some people who take CABOMETYX. Tell your healthcare provider if you plan to have any surgery before or during treatment with CABOMETYX.

  • You should stop taking CABOMETYX at least 3 weeks before planned surgery.
  • Your healthcare provider should tell you when you may start taking CABOMETYX again after surgery.

Reversible Posterior Leukoencephalopathy Syndrome (RPLS). A condition called reversible posterior leukoencephalopathy syndrome can happen during treatment with CABOMETYX. Tell your healthcare provider right away if you have headaches, seizures, confusion, changes in vision, or problems thinking.

CABOMETYX may cause fertility problems in females and males, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with CABOMETYX if you have certain side effects.

The most common side effects of CABOMETYX include:

  • Tiredness
  • Decreased appetite
  • Weight loss
  • Nausea
  • Vomiting
  • Changes in certain blood tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of CABOMETYX. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before you take CABOMETYX, tell your healthcare provider about all of your medical conditions, including if you:

  • Have a recent history of bleeding, including coughing up or vomiting blood, or black tarry stools.
  • Have an open or healing wound.
  • Have high blood pressure.
  • Plan to have any surgery, dental procedure, or have had a recent surgery. You should stop treatment with CABOMETYX at least 3 weeks before planned surgery.
  • Are pregnant, or plan to become pregnant. CABOMETYX can harm your unborn baby.
    • If you are able to become pregnant, your healthcare provider will check your pregnancy status before you start treatment with CABOMETYX.
    • Females who are able to become pregnant should use effective birth control (contraception) during treatment and for 4 months after your final dose of CABOMETYX.
    • Talk to your healthcare provider about birth control methods that may be right for you.
    • If you become pregnant or think you are pregnant, tell your healthcare provider right away.
  • Are breastfeeding or plan to breastfeed. It is not known if CABOMETYX passes into your breast milk. Do not breastfeed during treatment and for 4 months after your final dose of CABOMETYX.

Tell your healthcare provider about all the medicines you take, including prescription or over-the-counter medicines, vitamins, and herbal supplements. CABOMETYX and certain other medicines may affect each other causing side effects.

What should I avoid while taking CABOMETYX?
Do not drink grapefruit juice, eat grapefruit or take supplements that contain grapefruit or St. John's wort during treatment with CABOMETYX.

Please see the Patient Information in the accompanying full Prescribing Information.