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BE Resourceful

Resources for the treatment journey

Patient Care Kit

The Care Kit contains useful information and tools to help you or someone you are caring for while taking CABOMETYX.

If you have not received a Patient Care Kit, you can request one here.

request a kit

Limit one per patient, US residents only. Additional restrictions and eligibility rules apply. Exelixis may at its sole option modify these terms and conditions without notice.

CABOMETYX Patient Care Kit
CABOMETYX® Doctor Discussion Guide

Talking to Your Doctor

Sometimes it's hard to remember what you want to discuss or ask your healthcare team. Help make the most of your medical appointments by using this Doctor Discussion Guide to organize what you want to talk about regarding your treatment and goals:

  • Personalize topics that are important to you
  • See suggestions for topics you might want to discuss
  • Create new versions for each appointment
create your guide

Or Download a General Doctor Discussion Guide

CABOMETYX Patient Care Kit

BE CONNECTED with CABOMETYX® Support Program

The BE CONNECTED support program provides educational information for you or someone you are caring for who is taking CABOMETYX.

Learn More

Downloadable resources

CABOMETYX Handbook
Gives you an introduction to CABOMETYX treatment

Download
Descargar en Español
CABOMETYX Patient Handbook Cover

Handbook for certain people with advanced kidney cancer (RCC)
More information about CABOMETYX, including the results of clinical studies in kidney cancer

Download
Descargar en Español
CABOMETYX Advanced Kidney Cancer (RCC) Patient Handbook Cover

Neuroendocrine Tumors (NETs) Handbook
CABOMETYX is used to treat people ages 12 and older with previously treated neuroendocrine tumors (NETs), either pancreatic NET (pNET) or extra-pancreatic NET (epNET), that cannot be treated by surgery and have spread (locally advanced or metastatic). More information about CABOMETYX, including the results of clinical studies in NETs

Download
Descargar en Español
CABOMETYX patient handbook pdf


Handbook for people with liver cancer (HCC) previously treated with sorafenib
More information about CABOMETYX, including the results of clinical studies in liver cancer

Download
Descargar en Español
下载中文版本
CABOMETYX Liver Cancer (HCC) Patient Handbook Cover

Papillary or Follicular Thyroid Cancer (2 types of differentiated thyroid cancer) Handbook
For people ages 12 and older with previously treated advanced differentiated thyroid cancer (papillary or follicular) ineligible for radioactive iodine: More information about CABOMETYX, including the results of clinical studies in thyroid cancer

Download
Descargar en Español
CABOMETYX Differentiated Thyroid Cancer (DTC) Patient Handbook Cover

Treatment Journal
Helps you keep track of how you are feeling while taking CABOMETYX so you can keep your healthcare team informed

Download
Descargar en Español
CABOMETYX Treatment Journal Cover

Wallet Card
Helps you tell healthcare providers about all the medicines you take in addition to CABOMETYX

Download
Descargar en Español
CABOMETYX Wallet Card

Side Effect Tip Cards
Provide information that may help you manage certain side effects

Download
Descargar en Español
CABOMETYX Side Effect Tip Cards

Video resources

CABOMETYX Video Companion

Get answers to frequently asked questions about CABOMETYX. View a single topic or watch the entire video whenever you need info ASAP.

How Open Communication Helps Your Team Help You 1:15

How Open Communication Helps Your Team Help You

Staying Positive During Treatment 1:26

Staying Positive During Treatment

Explore by topic

Treatment Tips
Support & Resources Programs
About Cabometyx

Advocacy organizations

CancerCare®

1-800-813-HOPE (4673)
www.cancercare.org

American Cancer Society®

1-800-227-2345
www.cancer.org

The National Cancer Institute

1-800-4-CANCER (422-6237)
www.cancer.gov

Alliance for Clinical Trials in Oncology

Contact via website only
allianceforclinicaltrialsinoncology.org

Cancer Support Community

1-888-793-9355
www.cancersupportcommunity.org

Family Reach

Contact via website only
familyreach.org

For kidney cancer

CABOMETYX is used to treat people with advanced kidney cancer.

KCCure - Kidney Cancer Research Alliance

Contact via website only
www.kccure.org

Kidney Cancer Association

1-800-850-9132
www.kidneycancer.org

KidneyCAN

Contact via website only
www.kidneycan.org

National Kidney Foundation

1-855-653-2273
www.kidney.org

For neuroendocrine tumors

CABOMETYX is used to treat people ages 12 and older with previously treated advanced neuroendocrine tumors (NETs), either pancreatic NET (pNET) or extra-pancreatic NET (epNET), that cannot be treated by surgery and have spread (locally advanced or metastatic).

Healing NET Foundation

615-369-6463
www.thehealingnet.org

International Neuroendocrine Cancer Alliance

Contact via website only
incalliance.org

Neuroendocrine Cancer Foundation

Contact via website only
www.ncf.net

Neuroendocrine Cancer Awareness Network (NCAN)

866-850-9555
netcancerawareness.org

The Neuroendocrine Tumor Research Foundation

617-946-1780
netrf.org/for-patients

For liver cancer

CABOMETYX is used to treat people with liver cancer previously treated with sorafenib.

American Liver Foundation

1-800-465-4837
www.liverfoundation.org
  

Blue Faery: The Adrienne Wilson Liver Cancer Association

1-818-636-5624
www.bluefaery.org

For thyroid cancer

CABOMETYX is used to treat people ages 12 and older with previously treated advanced differentiated thyroid cancer (papillary or follicular) ineligible for radioactive iodine.

American Thyroid Association

Contact via website only
www.thyroid.org/thyroid-cancer

ThyCa: Thyroid Cancer Survivors’ Association

Contact via website only
www.thyca.org

National Organization for Rare Disorders

Contact via website only
www.rarediseases.org/thyroid-cancer

These are third-party organizations and websites that are not owned or controlled by Exelixis, Inc. and their inclusion does not constitute endorsement of CABOMETYX. Exelixis, Inc. makes no representation regarding the content, accuracy or completeness of the information provided by these organizations and on these third-party websites. Use and access to the information on these third-party websites are subject to the terms, limitations, and conditions set by those websites.

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Cost & Financial Support

Exelixis Access Services® (EASE) is your resource for questions and needs related to insurance coverage, financial assistance, and treatment support for CABOMETYX.

Learn More
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IMPORTANT SAFETY INFORMATION

What are the possible side effects of CABOMETYX?

CABOMETYX may cause serious side effects, including:

Bleeding (hemorrhage). CABOMETYX can cause severe bleeding that may lead to death. Tell your healthcare provider right away if you get any signs of bleeding during treatment with CABOMETYX, including:

  • coughing up blood or blood clots
  • vomiting blood or if your vomit looks like coffee grounds
  • red or black (looks like tar) stools
  • menstrual bleeding that is heavier than normal
  • any unusual or heavy bleeding

A tear in your stomach or intestinal wall (perforation) or an abnormal connection between 2 parts of your body (fistula). Tell your healthcare provider right away if you get tenderness or pain in your stomach area (abdomen) that is severe or that does not go away.

Blood clots, stroke, heart attack, and chest pain. Get emergency help right away for:

  • swelling or pain in your arms or legs
  • shortness of breath
  • feel lightheaded or faint
  • sweating more than usual
  • numbness or weakness of your face, arm, or leg, especially on one side of your body
  • sudden confusion, trouble speaking or understanding
  • sudden trouble seeing in one or both eyes
  • sudden trouble walking
  • dizziness, loss of balance or coordination
  • a sudden severe headache

High blood pressure (hypertension). Hypertension is common with CABOMETYX and sometimes can be severe. Your healthcare provider will check your blood pressure before starting CABOMETYX and regularly during treatment with CABOMETYX. If needed, your healthcare provider may prescribe medicine to treat your high blood pressure. Tell your healthcare provider if you develop severe headaches, nose bleeds, tiredness or confusion, vision changes, chest pain, trouble breathing, irregular heartbeat, or blood in your urine.

Heart problems. CABOMETYX can cause heart failure that may lead to death. Your healthcare provider may check your heart function before and during treatment with CABOMETYX. Tell your healthcare provider right away if you get any of the following signs and symptoms: feeling like your heart is pounding, racing, or beating irregularly; shortness of breath; swelling of your ankles or feet; feeling lightheaded; feeling tired.

Diarrhea. Diarrhea is common with CABOMETYX and can be severe. If needed, your healthcare provider may prescribe medicine to treat your diarrhea. Tell your healthcare provider right away if you have frequent loose, watery bowel movements.

A skin problem called hand-foot skin reaction. Hand-foot skin reactions are common with CABOMETYX and can be severe. Tell your healthcare provider right away if you have rashes, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet.

Liver problems. Liver problems may happen during treatment with CABOMETYX. When CABOMETYX is taken in combination with nivolumab, severe changes in liver function tests may happen more often than if you take CABOMETYX alone. Your healthcare provider will do blood tests to check your liver function before and during treatment with CABOMETYX. 
Tell your healthcare provider right away if you develop symptoms of liver problems including: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine, bleeding or bruising more easily than normal.

Adrenal gland problems. Your healthcare provider will monitor you for this problem. Your healthcare provider may prescribe hormone replacement therapy or corticosteroid medicines if needed. Tell your healthcare provider right away if you develop any of the following signs or symptoms: extreme tiredness, dizziness or fainting, weakness, nausea, or vomiting.

Protein in your urine and possible kidney problems. Symptoms may include swelling in your hands, arms, legs, or feet. Your healthcare provider will check you for this problem during treatment with CABOMETYX.

Severe jaw bone problems (osteonecrosis). Your healthcare provider should examine your mouth before you start and during treatment with CABOMETYX. Tell your dentist that you are taking CABOMETYX. It is important for you to practice good mouth care during treatment with CABOMETYX. Tell your healthcare provider right away if you develop any symptoms of jaw problems, including: jaw pain, toothache, or sores on your gums.

Wound healing problems. Wound healing problems have happened in people who take CABOMETYX. Tell your healthcare provider if you plan to have any surgery before or during treatment with CABOMETYX.

  • You should stop taking CABOMETYX at least 3 weeks before planned surgery.
  • Your healthcare provider should tell you when you may start taking CABOMETYX again after surgery.

Reversible posterior leukoencephalopathy syndrome (RPLS). A condition called reversible posterior leukoencephalopathy syndrome can happen during treatment with CABOMETYX. Tell your healthcare provider right away if you have headaches, seizures, confusion, changes in vision, or problems thinking.

Change in thyroid function. CABOMETYX can cause changes in your thyroid function, including changes to thyroid hormone levels in your blood. Your healthcare provider will do blood tests to check your thyroid function before and during treatment with CABOMETYX.

Decreased calcium level in your blood (hypocalcemia). CABOMETYX can cause you to have a decreased amount of calcium in your blood. Your healthcare provider will do blood tests to check you for this problem and give you calcium if needed. Tell your healthcare provider right away if you get any of the following signs or symptoms:

  • muscle stiffness or muscle spasms
  • numbness or tingling in your fingers, toes, or around your mouth
  • seizures
  • sudden weight gain
  • swelling of your arms, hands, legs, and ankles

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with CABOMETYX if you have certain side effects.

The most common side effects of CABOMETYX include:

  • tiredness
  • nausea and vomiting
  • constipation
  • decreased appetite
  • weight loss

The most common side effects of CABOMETYX when used with nivolumab include:

  • tiredness
  • mouth sores
  • rash
  • low thyroid hormone levels (hypothyroidism)
  • pain in muscles, bones, and joints
  • decreased appetite
  • nausea
  • changes in the way things taste
  • stomach-area (abdominal) pain
  • cough
  • upper respiratory tract infection

CABOMETYX may cause fertility problems in females and males, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all of the possible side effects of CABOMETYX. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

If your healthcare provider prescribes CABOMETYX in combination with nivolumab, also read the Medication Guide that comes with nivolumab.

Before you take CABOMETYX, tell your healthcare provider about all of your medical conditions, including if you:

  • have had a liver problem other than liver cancer.
  • have a recent history of bleeding, including coughing up or vomiting blood, or black tarry stools.
  • have an open or healing wound.
  • have high blood pressure.
  • have a low calcium level in your blood (hypocalcemia).
  • plan to have any surgery, dental procedure, or have had a recent surgery. You should stop treatment with CABOMETYX at least 3 weeks before planned surgery.
  • are pregnant, or plan to become pregnant. CABOMETYX can harm your unborn baby.
    • If you are able to become pregnant, your healthcare provider will check your pregnancy status before you start treatment with CABOMETYX.
    • Females who are able to become pregnant should use effective birth control (contraception) during treatment and for 4 months after your last dose of CABOMETYX.
    • Talk to your healthcare provider about birth control methods that may be right for you.
    • If you become pregnant or think you are pregnant, tell your healthcare provider right away.
  • are breastfeeding or plan to breastfeed. It is not known if CABOMETYX passes into your breast milk. Do not breastfeed during treatment and for 4 months after your last dose of CABOMETYX.

Tell your healthcare provider about all the medicines you take, including prescription or over-the-counter medicines, vitamins, and herbal supplements. CABOMETYX and certain other medicines may affect each other, causing side effects.

What should I avoid while taking CABOMETYX?

Avoid drinking grapefruit juice, eating grapefruit, or taking supplements that contain grapefruit or St. John’s wort during treatment with CABOMETYX.

Please see the Patient Information in the accompanying full Prescribing Information.

INDICATION

What is CABOMETYX?

CABOMETYX is a prescription medicine used to treat:

  • People with kidney cancer (renal cell carcinoma). CABOMETYX may be used:
    • In combination with nivolumab to treat people with renal cell carcinoma (RCC) that has spread (advanced RCC), and you have not already had treatment for your advanced RCC.
    • Alone to treat people with advanced RCC.
  • People with liver cancer (hepatocellular carcinoma) who have been previously treated with the medicine sorafenib.
  • Adults and children 12 years of age and older who have a type of thyroid cancer called differentiated thyroid cancer (DTC) that has spread (locally advanced or metastatic), and,
    • has progressed after treatment with a VEGFR-targeted treatment, and
    • your DTC can no longer be treated with radioactive iodine, or you are not able to receive radioactive iodine treatment.
  • Adults and children 12 years of age and older who have a type of cancer called pancreatic neuroendocrine tumors (pNET) or extra-pancreatic neuroendocrine tumors (epNET) that has been previously treated, cannot be treated by surgery, and has spread (locally advanced or metastatic).

It is not known if CABOMETYX is safe and effective in children younger than 12 years of age.

  • People with kidney cancer (renal cell carcinoma). CABOMETYX may be used:
    • In combination with nivolumab to treat renal cell carcinoma (RCC) that has spread (advanced RCC), and you have not already had treatment for your advanced RCC.
    • Alone to treat people with advanced RCC.
  • People with liver cancer (hepatocellular carcinoma) who have been previously treated with the medicine sorafenib.
  • Adults and children 12 years of age and older who have a type of thyroid cancer called differentiated thyroid cancer (DTC) that has spread (locally advanced or metastatic), and,
    • has progressed after treatment with a VEGFR-targeted treatment, and
    • your DTC can no longer be treated with radioactive iodine, or you are not able to receive radioactive iodine treatment.
  • Adults and children 12 years of age and older who have a type of cancer called pancreatic neuroendocrine tumors (pNET) or extra-pancreatic neuroendocrine tumors (epNET) that has been previously treated, cannot be treated by surgery, and has spread (locally advanced or metastatic).

It is not known if CABOMETYX is safe and effective in children younger than 12 years of age.