Doctor Discussion Guide

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Let’s start with some basic information

Tell us about yourself:

What is the diagnosed condition:

It helps to discuss treatment-related questions

Whether you’re just starting or have been taking CABOMETYX for a while, treatment questions can pop up. Taking your medicine exactly as prescribed by your healthcare team is important. That’s why it’s good to discuss any questions you may have. This guide is not medical advice—your healthcare team is your best resource to answer these questions and help solve any issues you may have.

I’d like to talk about:

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Communication is vital to help manage side effects

Tip: Download a free "Treatment Journal" to help you keep track of how you're feeling. Look under the "Resources" tab on the CABOMETYX website.

Your healthcare team has options to help manage certain side effects—but they have to know about them. The sooner you tell them what you are experiencing, the sooner they can help you. It helps to write down what you’re experiencing so you can be prepared to have a discussion. Remember: no issue is too small to tell your healthcare team.

I’d like to talk about:

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Or

Share important milestones and plans with your team

Tip: You can find information, tools, and more to help with CABOMETYX treatment on the website. Just click on the "Resources" tab on any page of the website.

You still have goals—whether it’s traveling for vacation, celebrating a family event, or simply walking your dog. Think about what meaningful activities you want to engage in now and in the future—then loop in your healthcare team. Together, you can figure out how best to accomplish what’s important to you.

I’d like to talk about:

Select as many topics as you need

Or

Tell your team if you want extra support during treatment

Your needs during treatment with CABOMETYX may change over time. It’s a good idea to take a moment to reflect on where you were, where you are now, and if your needs have changed. Support can be physical, emotional, or financial. This guide is not medical advice—whatever your needs are, your healthcare team has the experience to help you find the support you’re looking for.

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Thank you for your interest in CABOMETYX patient support

Your request has been received. We appreciate your interest in receiving support materials for CABOMETYX and we look forward to serving you. You will start receiving resources and patient support materials.

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You’re ready to talk with your healthcare team

You can now access your Doctor Discussion Guide. Remember to bring it with you to help make the most out of your appointment.

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MORE RESOURCES

CABOMETYX BE CONNECTED Logo

The BE CONNECTED support program provides educational information for you or someone you are caring for who is taking CABOMETYX.

CABOMETYX Support resources icon

Cancer Resources
There are many resources available for you or someone you are caring for to help throughout the treatment journey.

All About CABOMETYX

Learn more about CABOMETYX and how it may help.

Now you’re prepared to talk with your healthcare team

Your Doctor Discussion Guide is now complete. Remember to bring it with you to help make the most out of your appointment.

Get your Doctor Discussion Guide

You’re always welcome back!

It’s a great idea to create a new guide to prepare for each of your future appointments. This way, important concerns won’t get missed or forgotten—and that may help both you and your healthcare team have a better discussion.

MORE RESOURCES

CABOMETYX BE CONNECTED Logo

The BE CONNECTED support program provides educational information for you or someone you are caring for who is taking CABOMETYX.

CABOMETYX Support resources icon

Cost & Financial Support
Exelixis Access Services (EASE) is your resource for questions and needs related to insurance coverage, financial assistance, and treatment support for CABOMETYX® (cabozantinib).

All About CABOMETYX

Learn more about CABOMETYX and how it may help.

INDICATIONS AND IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION

What are the possible side effects of CABOMETYX?

CABOMETYX may cause serious side effects, including:

Bleeding (hemorrhage). CABOMETYX can cause severe bleeding that may lead to death. Tell your healthcare provider right away if you get any signs of bleeding during treatment with CABOMETYX, including:

  • Coughing up blood or blood clots
  • Vomiting blood or if your vomit looks like coffee grounds
  • Red or black (looks like tar) stools
  • Menstrual bleeding that is heavier than normal
  • Any unusual or heavy bleeding

A tear in your stomach or intestinal wall (perforation) or an abnormal connection between 2 parts of your body (fistula). Tell your healthcare provider right away if you get tenderness or pain in your stomach area (abdomen) that is severe or that does not go away.

Blood clots, stroke, heart attack, and chest pain. Get emergency help right away if you get:

  • Swelling or pain in your arms or legs
  • Shortness of breath
  • Feel lightheaded or faint
  • Sweating more than usual
  • Numbness or weakness of your face, arm, or leg, especially on one side of your body
  • Sudden confusion, trouble speaking or understanding
  • Sudden trouble seeing in one or both eyes
  • Sudden trouble walking
  • Dizziness, loss of balance or coordination
  • A sudden severe headache

High blood pressure (hypertension). Hypertension is common with CABOMETYX and sometimes can be severe. Your healthcare provider will check your blood pressure before starting CABOMETYX and regularly during treatment with CABOMETYX. If needed, your healthcare provider may prescribe medicine to treat your high blood pressure. Tell your healthcare provider if you develop severe headaches, nose bleeds, tiredness or confusion, vision changes, chest pain, trouble breathing, irregular heartbeat, or blood in your urine.

Diarrhea. Diarrhea is common with CABOMETYX and can be severe. If needed, your healthcare provider may prescribe medicine to treat your diarrhea. Tell your healthcare provider right away if you have frequent loose, watery bowel movements.

A skin problem called hand-foot skin reaction. Hand-foot skin reactions are common and can be severe. Tell your healthcare provider right away if you have rashes, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet.

Liver problems. Liver problems may happen during treatment with CABOMETYX. When CABOMETYX is taken in combination with nivolumab, severe changes in liver function tests may happen more often than if you take CABOMETYX alone. Your healthcare provider will do blood tests to check your liver function before and during treatment with CABOMETYX.

Tell your healthcare provider right away if you develop symptoms of liver problems including: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine, bleeding or bruising more easily than normal.

Adrenal gland problems. Your healthcare provider will monitor you for this problem. Your healthcare provider may prescribe hormone replacement therapy or corticosteroid medicines if needed. Tell your healthcare provider right away if you develop any of the following signs or symptoms: extreme tiredness, dizziness or fainting, weakness, nausea, or vomiting.

Protein in your urine and possible kidney problems. Symptoms may include swelling in your hands, arms, legs, or feet. Your healthcare provider will check you for this problem during treatment with CABOMETYX.

Severe jaw bone problems (osteonecrosis). Your healthcare provider should examine your mouth before you start and during treatment with CABOMETYX. Tell your dentist that you are taking CABOMETYX. It is important for you to practice good mouth care during treatment with CABOMETYX. Tell your healthcare provider right away if you develop any symptoms of jaw problems, including: jaw pain, toothache, or sores on your gums.

Wound healing problems. Wound healing problems have happened in people who take CABOMETYX. Tell your healthcare provider if you plan to have any surgery before or during treatment with CABOMETYX.

  • You should stop taking CABOMETYX at least 3 weeks before planned surgery.
  • Your healthcare provider should tell you when you may start taking CABOMETYX again after surgery.

Reversible posterior leukoencephalopathy syndrome (RPLS). A condition called reversible posterior leukoencephalopathy syndrome can happen during treatment with CABOMETYX. Tell your healthcare provider right away if you have headaches, seizures, confusion, changes in vision, or problems thinking.

Change in thyroid function. CABOMETYX can cause changes in your thyroid function, including changes to thyroid hormone levels in your blood. Your healthcare provider will do blood tests to check your thyroid function before and during treatment with CABOMETYX.

Decreased calcium level in your blood (hypocalcemia). CABOMETYX can cause you to have a decreased amount of calcium in your blood. Your healthcare provider will do blood tests to check you for this problem and give you calcium if needed. Tell your healthcare provider right away if you get any of the following signs or symptoms:

  • Muscle stiffness or muscle spasms
  • Numbness or tingling in your fingers, toes, or around your mouth
  • Seizures
  • Sudden weight gain
  • Swelling of your arms, hands, legs, and ankles

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with CABOMETYX if you have certain side effects.

The most common side effects of CABOMETYX include:

  • Tiredness
  • Decreased appetite
  • Nausea and vomiting
  • Weight loss
  • Constipation

The most common side effects of CABOMETYX when used with nivolumab include:

  • Tiredness
  • Mouth sores
  • Rash
  • Low thyroid hormone levels (hypothyroidism)
  • Pain in muscles, bones, and joints
  • Decreased appetite
  • Nausea
  • Changes in the way things taste
  • Stomach-area (abdominal) pain
  • Cough
  • Upper respiratory tract infection

CABOMETYX may cause fertility problems in females and males, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all of the possible side effects of CABOMETYX. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

If your healthcare provider prescribes CABOMETYX in combination with nivolumab, also read the Medication Guide that comes with nivolumab.

Before you take CABOMETYX, tell your healthcare provider about all of your medical conditions, including if you:

  • Have had a liver problem other than liver cancer.
  • Have a recent history of bleeding, including coughing up or vomiting blood, or black tarry stools.
  • Have an open or healing wound.
  • Have high blood pressure.
  • Have a low calcium level in your blood (hypocalcemia).
  • Plan to have any surgery, dental procedure, or have had a recent surgery. You should stop treatment with CABOMETYX at least 3 weeks before planned surgery.
  • Are pregnant, or plan to become pregnant. CABOMETYX can harm your unborn baby.
    • If you are able to become pregnant, your healthcare provider will check your pregnancy status before you start treatment with CABOMETYX.
    • Females who are able to become pregnant should use effective birth control (contraception) during treatment and for 4 months after your final dose of CABOMETYX.
    • Talk to your healthcare provider about birth control methods that may be right for you.
    • If you become pregnant or think you are pregnant, tell your healthcare provider right away.
  • Are breastfeeding or plan to breastfeed. It is not known if CABOMETYX passes into your breast milk. Do not breastfeed during treatment and for 4 months after your final dose of CABOMETYX.

Tell your healthcare provider about all the medicines you take, including prescription or over-the-counter medicines, vitamins, and herbal supplements. CABOMETYX and certain other medicines may affect each other, causing side effects.

What should I avoid while taking CABOMETYX?

Avoid drinking grapefruit juice, eating grapefruit, or taking supplements that contain grapefruit or St. John’s wort during treatment with CABOMETYX.

Please see the Patient Information in the full Prescribing Information.

INDICATION

What is CABOMETYX?

CABOMETYX is a prescription medicine used to treat:

  • People with kidney cancer (renal cell carcinoma). CABOMETYX may be used:
    • In combination with nivolumab to treat renal cell carcinoma (RCC) that has spread (advanced RCC), and you have not already had treatment for your advanced RCC
    • Alone to treat people with renal cell carcinoma (RCC) that has spread (advanced RCC)
  • People with kidney cancer (renal cell carcinoma). CABOMETYX may be used:
    • In combination with nivolumab to treat renal cell carcinoma (RCC) that has spread (advanced RCC), and you have not already had treatment for your advanced RCC
    • Alone to treat people with renal cell carcinoma (RCC) that has spread (advanced RCC)